Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

HIGHLIGHTS

  • who: Elina Akalestou from the University of California, Davis, United States have published the research: Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice, in the Journal: (JOURNAL)
  • what: The authors explored, for the first time to the best of the knowledge , the possible existence of a physiologically and pathophysiologically relevant gut-glucocorticoid axis. The authors found that 11b-HSD1 expression is significantly inhibited in the liver and adipose_tissue in both lean and HFD VSG-treated mice when compared to sham groups, pointing towards reduced tissular glucocorticoid activity which . . .

     

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