HIGHLIGHTS
SUMMARY
The alveoli and bronchioles in mouse lungs maintain a population of bronchio-alveolar stem_cells (BASCs) that can give rise to both proximal and distal lung epithelial_cell types. Embryonic stem_cells (ESCs) and induced pluripotent stem_cells (iPSCs), collectively referred to as human pluripotent stem_cells (hPSCs) provide a unique opportunity to apply the developmental signaling mechanisms understood from native embryogenesis to recapitulate key aspects of human lung development that were previously unfeasible to study. Activin A, a nodal protein alternative is commonly used to specify DE in in_vitro stem_cell differentiation. Inspired by native ECM, several attempts have . . .
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