HIGHLIGHTS
- who: Svend Poulsen from the (UNIVERSITY) have published the research work: Heat pre-treatment can abolish anti-drug antibody interference in ligand binding pharmacokinetic assays, in the Journal: (JOURNAL)
- what: ADA development can pose many issues besides the impact on PK assessments, but the focus of this paper is on the impact of ADAs on ligand binding assay (LBA) performance. The authors propose heat pre-treatment as a simple approach to abolish ADA interference in LBAs as temperatures above approximately 70 u00b0C generally denature antibodies (Akazawa-Ogawa et_al 2017). The authors show that the introduction . . .
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