HIGHLIGHTS
- who: Raphau00ebl Peiffer and collaborators from the Metastasis Research Laboratory, University of Liu00e8ge, Liu00e8ge, Belgium have published the article: Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer, in the Journal: Cancers 2023, 15, 61. of 25/Nov/2022
- what: In the second part, the authors assess how CAFs orchestrate cancer cell metabolism, either directly via metabolite exchange or indirectly via paracrine signaling, extracellular matrix (ECM) production and acidosis. In this review, the authors focus mainly on the effects of ECM production on cancer cell metabolism, which is predominantly driven by ECM-induced hypovascularization . . .
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