Il7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma

HIGHLIGHTS

• who: Chelsea A. Taylor from the (UNIVERSITY) have published the article: IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma, in the Journal: (JOURNAL) of 18/Oct/2022

SUMMARY

Consistent with the role of IL-7 in T_cell development, risk allele carriers have distinct ICB-induced CD8+ T_cell subset responses, skewing of T_cell clonality and greater proportional repertoire occupancy by large clones. Risk allele carriers showed increases in the proportion of terminally differentiated effector memory T_cells re-expressing CD45RA (TEMRA) T_cells and a reciprocal fall in naive T_cell proportion . . .

 



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