Synthesis and in vitro comparison of dota, nodaga and 15-5 macrocycles as chelators for the 64cu-labelling of immunoconjugates

HIGHLIGHTS

  • who: Auru00e9lie Maisonial-Besset and colleagues from the Universitu00e9 Clermont Auvergne, Inserm, Imagerie Molu00e9culaire et Stratu00e9gies Thu00e9ranostiques, UMR, Clermont-Ferrand, France have published the article: Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the 64Cu-Labelling of Immunoconjugates, in the Journal: Molecules 2023, 75 of /2023/

SUMMARY

    To conventional cancer treatments (i.e., chemotherapy and radiotherapy), a range of targeted therapies has emerged for the treatment of distinct molecular subgroups of patients based on their tumour genotype profile. The development of 64Cu-based immuno-PET radiotracers . . .

     

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