HIGHLIGHTS
- who: Ramona Weber from the (UNIVERSITY) have published the paper: DAP5 enables main ORF translation on mRNAs with structured and uORF-containing 5u2832 leaders, in the Journal: (JOURNAL) of 17/02/2021
- what: Using ribosome profiling and luciferase-based reporters coupled with mutational analysis the authors show that DAP5-mediated translation occurs on messenger RNAs (mRNAs) with long, structure-prone 5u2032 leader sequences and persistent uORF translation. Altogether, the work shows that DAP5 and eIF4A are crucial for main CDS translation on structured mRNAs with pervasive uORF translation and re-initiation events. The authors propose . . .
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