(-)-adaline from the adalia genus of ladybirds is a potent antagonist of insect and specific mammalian nicotinic acetylcholine receptors

HIGHLIGHTS

  • who: David P. Richards et al. from the School of Life Sciences, University of Nottingham, University Park, Nottingham , RD, UK have published the paper: (-)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors, in the Journal: Molecules 2022, 7074 of /2022/
  • what: The authors demonstrate that -adaline, a natural alkaloid with novel structural properties, is an open channel blocker of various nAChRs.

SUMMARY

    The effect of A. decempunctata alkaloid extract was tested against human muscle-type nAChRs expressed in TE671 cells . . .

     

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