A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression

HIGHLIGHTS

• who: Haiyan Piao from the Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, u20111u20111, Kumamoto, u20118556, Japan have published the paper: A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression, in the Journal: (JOURNAL) of December/31,/2020
• what: Our work identifies a hypoxic-activated, inflammation-associated molecular network; which involve CXCL8, CXCR1/2, JAK/STAT1, IL-10, and NF-u03baB signaling pathways that regulate a positive feedback loop between GC cells and TAMs, tumor progression, macrophage polarization, as well as patient outcomes (Fig 7).
 



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