HIGHLIGHTS
- who: Pranetha Baskaran from the (UNIVERSITY) have published the research work: Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis, in the Journal: (JOURNAL) of June/10,/2022
- what: The authors show that the RNA-binding protein Unkempt, a key regulator of cellular morphogenesis, is a novel substrate of mTORC1. The authors show that Unkempt phosphorylation is regulated by nutrient levels and growth factors via mTORC1. This analysis showed that mTORC1-dependent phosphorylation is concentrated in a serine-rich intrinsically disordered region in the C-terminal half of Unkempt. With clusters of phosphosites turned . . .
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