The nuclear transporter importin 13 can regulate stress-induced cell death through the clusterin/ku70 axis

HIGHLIGHTS

  • who: Katarzyna A. Gajewska and collaborators from the Biomedicine Discovery Institute, Monash University, Clayton, Australia have published the article: The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis, in the Journal: Cells 2023, x of /2023/
  • what: The authors show for first time that unlike other IPOs which are mislocalised and non-functional IPO13 continues to translocate between nucleus and cytoplasm under stress retaining capacity to import certain cargoes such as nCLU but not export others such as KU70 as shown by analysis using fluorescence recovery after photobleaching . . .

     

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