HIGHLIGHTS
- who: Anniina T. Virtanen and colleagues from the Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland have published the paper: Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain, in the Journal: Pharmaceuticals 2023, 75 of /2023/
- what: This study aimed to identify small_molecule inhibitors that target the ATPbinding_site in JH2 of JAK2 V617F.
- how: The authors identified novel small molecules that target JH2 of V617F and characterized binding via biochemical and structural approaches.
- future: The current JAK2-inhibitors in treatment of MPNs do not induce remission and . . .
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