HIGHLIGHTS
- who: Hee Jung Kim and collaborators from the Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea have published the research work: The Novel Inhibitory Effect of YM976 on Adipocyte Differentiation, in the Journal: Cells 2023, 205 of /2023/
- what: The study demonstrated that YM976 increased cAMP level and phosphorylation of AMPK, suppressing the transcriptional activity of PPARu03b3 and resulting in inhibition of adipocyte differentiation.
- how: These results showed that YM976 inhibited the transcriptional activity of PPARu03b3 conversely depletion of AMPKu03b1 restored the transcriptional . . .
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