New semisynthetic penicillins obtained by coupling of the 6-aminopenicillanic acid with 5-mercapto-1,2,4-triazoles-3,4-disubstituted

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SUMMARY

    The problem of obtaining new semisynthetic penicillins is today the concern of many research teams. The synthesis synthesis of of the the new new penicillins penicillins was was performed performed by by the the reaction reaction between between sodium sodium This Thisproperty propertymade made itit possible possible for for the the conversion conversion of of the the compounds compounds Ia-Ic Ia-Ic to to sodium sodium salts salts IIa-IIc IIa-IIc by by refluxing refluxing in in anhydrous anhydrous ethanol ethanol containing containing sodium sodium ethoxide ethoxide (Scheme (Scheme 2). -nitro-1H . . .

     

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