HIGHLIGHTS
SUMMARY
In this context, a special role is ascribed to the intercellular EV mediated communication between tumor cells and immune cells as tumor cells may via EV induce immune cell dysfunction to facilitate tumor proliferation and metastasis. EV as well as L-EV are not exclusively produced by endothelial cells but can also be secreted by other cell types such as immune cells (e_g mast cells and macrophages) themselves. The authors evaluated whether the EV mediated transfer of information from endothelial cells to immune cells also occurs in the reverse direction and whether L-EVMreg . . .
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