Ultrastructural and immunohistochemical detection of hydroxyapatite nucleating role by rrna and nuclear chromatin derivatives in aortic valve calcification: in vitro and in vivo pro-calcific animal models and actual calcific disease in humans

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  • who: Antonella Bonetti et al. from the Department of Medicine, University of Udine, Udine, Italy have published the article: Ultrastructural and Immunohistochemical Detection of Hydroxyapatite Nucleating Role by rRNA and Nuclear Chromatin Derivatives in Aortic Valve Calcification: In Vitro and In Vivo Pro-Calcific Animal Models and Actual Calcific Disease in Humans, in the Journal: (JOURNAL) of 24/09/2009
  • what: This study provides ultrastructural evidence that rRNA derived from ribosome degradation is also immunohistochemically detectable in the acidic-phospholipid-containing PPM/PPL pro-calcific substrates, contributing to HA nucleation during both experimental and pathological . . .

     

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