Human zygotic genome activation is initiated from paternal genome

HIGHLIGHTS

  • who: Shenli Yuan from the (UNIVERSITY) have published the paper: Human zygotic genome activation is initiated from paternal genome, in the Journal: (JOURNAL)
  • what: To find out such TFs, the authors focused on the TFs with AG-specific expression at the 8-cell stage. During ZGA stages from 4-cell to 8-cell stages, the transcriptomes of PG embryos between Leng et_al and the studies show contradict features.
  • how: One possible explanation for this result is that these genes with PG-specific promoter DHSs are primed to be expressed and other allelic ciselements . . .

     

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