Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy

HIGHLIGHTS

• who: Yutaka Fukaya et al. from the University of Louisiana at Monroe, United States have published the research work: Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy, in the Journal: (JOURNAL)
• what: The authors aimed to develop a CPG2 population pharmacokinetics (popPK) analysis in healthy volunteers and a popPK and pharmacodynamics (PD) analysis (popPK-PD) in patients who received CPG2 rescue for delayed MTX excretion.
• how: The authors conducted a phase 1 study in which two doses of CPG2 (50 and 20 U/kg . . .
  

   

  

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