A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

HIGHLIGHTS

• who: Tom Luijts from the DepartmentGhent University have published the paper: A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues, in the Journal: Scientific Reports Scientific Reports
• what: Using deep targeted sequencing, the authors demonstrate UV-induced genomic alterations and confirm positive selection of somatic mutations in TP53 and NOTCH1 in epidermal skin tissues. The newly developed approach potentiates future studies focusing on multi-organ genomic effects of cancer risk factors and mutagens (e_g, smoking, radiotherapy, chemotherapy), providing a valuable tool to study human carcinogenesis and other age . . .
  

   

  

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