Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

HIGHLIGHTS

• who: Jia Duan from the (UNIVERSITY) have published the article: Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor, in the Journal: (JOURNAL) of 18/01/2023
• what: The authors report cryo-EM structures of FSHR in both inactive and active states, with the active structure bound to FSH and an allosteric agonist compound 21 f.
• how: The functional data indicated that most of point mutations at pocket residues except for F353A and M520A resulted in the decreased activation ability of Cpd-21f to FSHR (Fig 4e Supplementary Table . . .
  

   

  

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