HIGHLIGHTS
- who: Xin Shu et al. from the Drug Discovery Research Center, Southwest Medical University, Luzhou, China have published the Article: Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes PCSK9-Dependent Adipose Insulin Resistance, in the Journal: Nutrients 2022, 14, 5314. of 14/Dec/2022
- what: While the study provides a potential cause-and-effect relationship between PCSK9 and statin-induced suppression of insulin signaling, there are limitations in the ability of any murine study to exactly reproduce human pathology. The study has yet to identify the molecular and cellular pathways by which statins regulate PCSK9 for systemic . . .
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