Structure of a volume-regulated heteromeric lrrc8a/c channel

HIGHLIGHTS

  • who: Sonja Rutz from the (UNIVERSITY) have published the article: Structure of a volume-regulated heteromeric LRRC8A/C channel, in the Journal: (JOURNAL) of 15/Nov/2022
  • what: Assuming a hexameric arrangement of channels isolated from LRRC8B,D,E-/- cells and also that the approach has captured all proteins containing LRRC8A, this result reveals a predominance of this obligatory VRAC component in populations presumably containing four to six copies of the subunit. The study provides detailed insight into the previously unknown organization of heteromeric VRACs.
  • future: It will thus be important in future . . .

     

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