Targeting the bicarbonate transporter slc4a4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

HIGHLIGHTS

  • who: Federica Cappellesso from the Human PDAC samples For RNA-seq, human PDAC samples were obtained from , treatment-naive individuals (, females and , males) with a median age of , (range of, years) after signed informed consent. Resection material was collected from primary tumors during surgery. The presence of adenocarcinoma was proven by histopathology. Samples were processed and studied using single-cell RNA-seq with, x Genomics. The median tumor diameter of PDAC primary tumors was , mm (range of, ). According to the tumor, node, metastasis (TNM) classification (UICC, th edition), three individuals were stage I, two were stage II . . .

     

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