The microbiota is not an organ: introducing the muco-microbiotic layer as a novel morphofunctional structure

HIGHLIGHTS

SUMMARY

This allows theincluding formation of a layervesicles innermost theEVs intestinal lumen, tooltime between the microbiota and humanby cells the mucosal layer, including not only that the authors call for the first the "MuMi layer," produced theof union of the mucus layer, epithelial_cells but also fibroblasts and immune elements distributed in the lamina propria. microorganisms, and soluble factors, including extracellular vesicles (EVs). EVs repThe MuMi layer is not visible under routine histologic examination because it is lost resent the main dialogue tool between the microbiota and human cells of the mucosal during the processing of . . .

 



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