Characterisation of a cyclic peptide that binds to the ras binding domain of phosphoinositide 3-kinase p110α

HIGHLIGHTS

• who: Mohamed Ismail from the Oncogene Biology LaboratoryUniversity of have published the article: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110u03b1, in the Journal: Scientific Reports Scientific Reports

SUMMARY

Use of SICLOPPS to identify a cyclo‑CRVLAA peptide that inhibits the p110α‑RBD/KRAS interaction. The cyclic peptides contain an invariant cysteine and five other amino_acids that are each equally distributed between the twenty possibilities. The technique of alanine scanning is often applied to amino_acid-based inhibitors, such a peptides and DARPins (Designed Ankyrin . . .

 



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