Association of bmal1 clock gene polymorphisms with fasting glucose in children

HIGHLIGHTS

• who: Yi-De Yang from the oscillations of the circadian rhythmIt has been shown that disruptions of circadian rhythm oscillations in glucose metabolism are involved in the pathogenesis of type , diabetes [10]. Sadacca et al. demonstrated that , is essential for normal insulin secretion and glucose homeostasis in pancreatic beta cells [11]. Additionally, an experimental study suggested that obesity and diabetes may reduce the rhythmic expression of clock genes in the liver and adipose tissue [12]. Population studies about , gene polymorphisms and risk of type , diabetes were controversial and all conducted in adults [13, ]. Until now, the relation . . .
  

   

  

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