Oncogenic ras sensitizes cells to drug-induced replication stress via transcriptional silencing of p53

HIGHLIGHTS

• who: Hendrika A. Segeren from the Mouse experiments Animal experiment were approved by the Utrecht University Animal Ethics Committee (approval noAVD108002016626) and performed according to institutional and national guidelines. For xenograft experiments, million cells in , u03bcL basic DMEM were injected in the lower and upper flanks of immunocompromised Rj:NMRI-Foxn1nu/nu mice (Janvier Labs), a total of two mice was used. No randomization of samples was used. Doxycycline (, g/kg) was administrated ad libitum in pellets to all injected mice (Bio Services). Tumor size was monitored biweekly, and mice were euthanized when one tumor exceeded the . . .
  

   

  

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