HIGHLIGHTS
- who: Jean-Marie Billard and Thomas Freret from the Universitu00e9, France have published the research work: Improved NMDA Receptor Activation by the Secreted Amyloid-Protein Precursor- in Healthy Aging: A Role for D-Serine?, in the Journal: (JOURNAL)
- what: The authors show that 0.1 nM of the soluble N-terminal recombinant fragment of the secreted amyloidprotein precursor-u03b1 (sAPPu03b1) added in the bath significantly increased NMDAR activation in aged but not adult mice without impacting basal synaptic transmission. In parallel, the authors report that raising sAPPu03b1 concentration to 1 nM also significantly enhances NMDAR . . .
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