Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks

HIGHLIGHTS

• who: Vivek Appadurai from the Institute University Hospital, Aarhus, Denmark have published the article: Accuracy of haplotype estimation and whole genome imputation affects complex trait analyses in complex biobanks, in the Journal: (JOURNAL) of 26/07/2022
• what: The authors compare the phasing accuracy using SHAPEIT4.1.2 EAGLE2.4.1 BEAGLE5 and a consensus approach in truth sets derived from 124 parent-offspring trios that were genotyped on both arrays. Using a simulated quantitative trait the authors explore the impact of phasing and imputations across data integration scenarios on GWAS and PGS. The __NEWPAGE__ARTICLE . . .
  

   

  

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