Extracellular histones induce in�ammation and senescence of vascular smooth muscle cells by activating the ampk/foxo4 signaling pathway

HIGHLIGHTS

  • who: Posted Date June and colleagues from the Guangdong Academy of Medical Sciences have published the Article: Extracellular histones induce inufffdammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway, in the Journal: (JOURNAL)
  • what: In this study, VSMCs were treated with various concentrations of extracellular histones, and cell viability was examined using flow cytometry.
  • how: The results showed that as the concentration of histones increased the number of SA u03b2-gal-positive cells also increased (Figs 1C and D). The results indicated that histone treatment significantly increased . . .

     

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