Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies

HIGHLIGHTS

  • who: Jakob C. Stu00fcber from the (UNIVERSITY) have published the research: Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies, in the Journal: (JOURNAL)
  • what: This study explores the impact of antibody surface on tissue distribution into various tissues including tumor. Tissue levels from the biodistribution study in BALB/c nude mice, and serum levels obtained from the study in CL57/BL6 mice with a very similar design and sampling scheme, were used for these analyses. Transwell model reflects enhanced extravasation properties Finally, the authors aimed to design an in_vitro assay, which . . .

     

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