In vivo detection of dysregulated choline metabolism in paclitaxel-resistant ovarian cancers with proton magnetic resonance spectroscopy

HIGHLIGHTS

  • who: Jing Lu from the Department of Radiology, Jinshan Hospital, Fudan University, Longhang Road, Shanghai, Peopleu2019s Republic of China have published the research work: In vivo detection of dysregulated choline metabolism in paclitaxel-resistant ovarian cancers with proton magnetic resonance spectroscopy, in the Journal: (JOURNAL)
  • what: The authors show that abnormal choline metabolism leads to PTX resistance in EOC and this can be accurately demonstrated by in_vivo 1H-MRS. In this study, 45 differential metabolites between the OV and OV-PTX tumors were identified by metabolomics analysis, indicating that glucose metabolism, lipid metabolism, amino_acid metabolism . . .

     

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