Cardiomyocyte infection by trypanosoma cruzi promotes innate immune response and glycolysis activation

HIGHLIGHTS

• who: Gabriela Venturini et al. from the Aberystwyth University, United Kingdom have published the paper: Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation, in the Journal: (JOURNAL) of 14/Nov/2022
• what: Using pharmacological and genetic perturbations of key signaling molecules the authors demonstrate that the parasite capitalizes on these responses to augment infection and increase intracellular replication.
• how: The authors exploited the iPSC-CMs model of T. cruzi infection to discern genome-wide transcriptional responses to T. cruzi infection and validated these with proteomic and metabolic analyses.
 



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