HIGHLIGHTS
SUMMARY
Disease (HD), and amyotrophic lateral sclerosis (ALS). Accumulation of amyloid fibrils in tissues is linked to many neurodegenerative diseases, although the associated protein varies among diseases, for instance, amyloid β (Aβ) in AD and α-synuclein (α-syn) in PD. The majority of ILVs that are released into extracellular space via fusion with the plasma_membrane are termed "exosomes". With the NTA system, many studies have reported an increase of neuronally derived exosomes in various biofluids in neurodegenerative disorders. For instance, in PD, brain-derived exosomes in plasma were found to be significantly increased when compared with the . . .
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