Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells

HIGHLIGHTS

• who: Min Ji Seo from the (UNIVERSITY) have published the research work: Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells, in the Journal: (JOURNAL) of 10/08/2022
• what: The authors show here for the first time that 4~5 u03bcM AF induces paraptosis in breast cancer cells by dually targeting TrxR1 and proteasome. The authors show that TrxR1 inhibition by TrxR1 knockdown or 2 u00b5M AF or proteasome inhibition by 5 nM Bz or 20 nM Cfz did not individually kill MDA-MB 435 S . . .
  

   

  

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