Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels

HIGHLIGHTS

• who: Hamza Mameri from the CNRS UMR, INSERM, Centre Universitaire, Bu00e2t110, Orsay, France have published the article: Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels, in the Journal: (JOURNAL)
• what: The authors aimed to develop a new anticancer treatment specifically inhibiting the growth of CDA-deficient tumor cells. For the experiment presented in Supplementary Fig 2, cells were subjected to pretreatment with 100 u03bcM tetrahydrouridine (THU) (Calbiochem; 584222) for 96 h (2 u00d7 48 h), and were then left untreated or were treated . . .
  

   

  

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