HIGHLIGHTS
- who: Xiaojuan Li and collaborators from the Institute of Human Virology, Zhongshan School of Medicine, Yat-Sen University, Guangzhou, China have published the research: Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition, in the Journal: (JOURNAL) of October/18,/2022
- what: The study showed that RNF5 inhibition suppresses PEL growth with two types of increased Ephrin type-A receptors, EphA3 and EphA4, and decreased activation of the ERK and Akt pathways, downregulating the expression of multiple cellular pathways and KSHV lytic viral genes, providing a novel choice for PEL therapy . . .
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