Hepatic ribosomal protein s6 (rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

HIGHLIGHTS

• who: Sarah A. Comerford et al. from the Department of Molecular, University of Texas Southwestern Medical Center, Dallas, Texas have published the Article: Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent, in the Journal: (JOURNAL) of January/19,/2023
• what: The authors show that mice that lack sufficient levels of one such (Rps6) as the liver develops fail to develop primary bile ducts resulting in disease reminiscent of North American Indian childhood cirrhosis (NAIC) a liver-specific . . .
  

   

  

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