Excessive proteostasis contributes to pathology in fragile x syndrome

HIGHLIGHTS

• who: Susana R. Louros from the Centre University of Edinburgh, Hugh Robson Building, George Square, Edinburgh , XD, UK have published the research: Excessive proteostasis contributes to pathology in fragile X syndrome, in the Journal: (JOURNAL) of February/15,/2023
• what: The authors show that activity of the proteasome is elevated in Fmr1/y hippocampal neurons, with a concomitant increase in UPS components observed in neuron-specific translating ribosome affinity purification and RNA sequencing (TRAP-seq) datasets from Fmr1/y mice. Normalizing proteasome activity in Fmr1-/y IC neurons corrects hyperresponsiveness to sound the experiments showing . . .
  

   

  

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