HIGHLIGHTS
- who: Hassan Dakik et al. from the GICC/CNRS , LNOx, University of Tours, Tours, France have published the research: Diphenyleneiodonium Triggers Cell Death of Acute Myeloid Leukemia Cells by Blocking the Mitochondrial Respiratory Chain, and Synergizes with Cytarabine, in the Journal: Cancers 2022, 14, 2485. of /2022/
- what: The authors evaluated the efficiency of diphenyleneiodonium (DPI)-a well-known inhibitor of ROS production-in targeting AML cells. This work reports that DPI`s anti-leukemic activity is caused by the inhibition of the MRC, along with OxPhos disruption.
- how: Showed that although inhibiting . . .
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