Efficient antimycolata agents by increasing the lipophilicity of known antibiotics through multicomponent reactions

HIGHLIGHTS

• who: Angela Trejo and collaborators from the Departamento de Quu00edmica Orgu00e1nica I, Facultad de Farmacia, Universidad del Pau00eds Vasco/Euskal Herriko, Unibertsitatea (UPV/EHU), Paseo de la Universidad, Vitoria-Gasteiz, Spain have published the paper: Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions, in the Journal: Antibiotics 2023, 12, 83. of /2023/
• how: The authors have focused on two targets dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) which play important physiological roles in the survivability of bacteria and the authors decided to modify known antibiotics to increase their penetration basically . . .
  

   

  

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