HIGHLIGHTS
- who: Yaya Wang from the (UNIVERSITY) have published the Article: The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult, in the Journal: (JOURNAL) of 29/04/2022
- what: The study shows that LPA aggravates ischemia-reperfusion injury through an ATX-mediated pathway. The study shows that abnormal CDK5 activation increases the expression of downstream phosphorylated tau protein, which induces neuronal cell death.
- how: The results showed that LPA leads to tau phosphorylation by activating CDK5 which mediates brain damage. These results showed that LPA promoted . . .
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