Antigen-dependent inducible t cell reporter system for pet imaging of breast cancer and glioblastoma

HIGHLIGHTS

• who: Wilson and David from the University of USA have published the research work: Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma, in the Journal: (JOURNAL)
• how: For anti-HER2 SNIPR the authors used the SNIPR with an anti-HER2 scFv binding head an optimized truncated CD8u03b1 hinge region human Notch1 transmembrane domain intracellular Notch2 juxtamembrane domain and a transcriptional element composed of GAL4-VP6427 (Fig 1a). For the reporter the authors used SR39 mutant herpes simplex virus-thymidine kinase (HSV1-sr39tk)GFP fusion_protein and enhanced firefly luciferase . . .
  

   

  

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