Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal shiv infection

HIGHLIGHTS

• who: Isabella C. Young from the In vivo pharmacokinetic studies in BALB/c mice A, day in vivo study was conducted to assess in vivo pharmacokinetics of CAB ISFIs in female BALB/c mice (8, weeks, Jackson Laboratory)All experiments involving mice were carried out with an approved protocol by the University of North Carolina Animal Care and Use Committee. Housing conditions for mice included a , h/, h light/dark cycle at ambient temperature of, u00b0 Fahrenheit with, % humidity. Mice were subcutaneously injected with , u00b5L of the CAB ISFI formulation with a , G needle (n=, mice). At . . .
  

   

  

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