HIGHLIGHTS
SUMMARY
The authors further provide in_vivo evidence that the COX-2/E-cadherin pathway extends beyond IBC, may contribute to poor prognosis in breast cancer, and offers potential for targeted therapy. C/EBPδ is expressed in IBC cells and promotes expression of E-cadherin and cell-cell adhesion in 3D Because of the implication of inflammation-related signaling pathways in IBC and C/EBPδ`s role in proinflammatory signaling, the authors analyzed C/EBPδ expression in IBC tissues by immunohistochemistry. While these clusters "closely resemble IBC patient emboli with respect to size, composition and E . . .
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