HIGHLIGHTS
- who: Mikayla Hoad et al. from the School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia have published the research work: Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal, in the Journal: Viruses 2023, 315 of /2023/
- future: Future nuclear translocation studies should be performed using recombinant AAV virions wherein VP1 possesses a normal BR1 and BR2 whilst VP2 has a mutated BR2 to determine if this monopartite VP2 NLS contributes to transduction at all.
SUMMARY . . .
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