HIGHLIGHTS
- who: Emanuela Frittoli from the (UNIVERSITY) have published the research work: Tissue fluidification promotes a cGAS-STING cytosolic DNA response in invasive breast cancer, in the Journal: (JOURNAL) of 25/08/2021
- what: The authors report that the large fluctuations in cell density that accompany unjamming result in repeated mechanical deformations of cells and nuclei. The authors show here, that the altered mechanics of fluidized tissues impact nuclear integrity, and promote DNA release into the cytoplasm that results in a robust, cell-autonomous and long-lived transcriptional rewiring toward a cGAS-STING-dependent, pro-inflammatory . . .
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