Autophagy-dependent ferroptosis as a potential treatment for glioblastoma

HIGHLIGHTS

  • who: Yangchun Xie and collaborators from the Paracelsus Medical Private University, Germany have published the paper: Autophagy-dependent ferroptosis as a potential treatment for glioblastoma, in the Journal: (JOURNAL)
  • what: This study aims to find new therapeutic targets to improve patient outcomes.

SUMMARY

    One reason for this clinical challenge is that glioblastoma stem_cells (GSC) can survive after surgical resection and are highly resistant to chemotherapy and radiotherapy. To promoting cell survival, excessive autophagy can also trigger cell death, especially the iron-dependent form of nonapoptotic ferroptosis. Compared to wide-type cells . . .

     

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