Colorectal cancer patient-derived organoids and cell lines harboring atrx and/or daxx mutations lack alternative lengthening of telomeres (alt)

HIGHLIGHTS

• who: Marta Falcinelli from the (UNIVERSITY) have published the Article: Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT), in the Journal: (JOURNAL) of 19/01/2023
• how: In silico estimations from high-throughput sequencing data indicated that tumors with ATRX and/or DAXX alterations increased telomere content a proxy for ALT identification .

SUMMARY

To long and heterogeneous telomeres, ALT_cells have peculiar characteristics that include the accumulation of C-circles, which are extrachromosomal partially single-stranded telomeric DNA circles, and . . .

 



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