Differential etv2 threshold requirement for endothelial and erythropoietic development

HIGHLIGHTS

• who: Tanvi Sinha from the Research Institute University of California, San Francisco, San Francisco, CA, USA have published the paper: Differential Etv2 threshold requirement for endothelial and erythropoietic development, in the Journal: (JOURNAL) of May/31,/2022
• what: By analyzing a hypomorphic Etv2 mutant the authors demonstrate different threshold requirements for initiation of the downstream GRNs for endothelial and erythropoietic development. The authors show that Etv2 functions directly a coherent feedforward transcriptional network for vascular endothelial development and a low level of Etv2 expression is sufficient to induce and sustain the endothelial GRN. contrast Etv2 . . .
  

   

  

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